CRM197

US FDA DMF Number Available
GMP-Grade and R&D-Grade Material Available

CRM197 (Cross Reacting Material 197) is a non-toxic, 58 kDa variant of diphtheria toxin that has been evaluated in animal studies. It is commonly used as a vaccine carrier protein, where chemical conjugation to polysaccharide antigens helps promote T-cell-dependent immune responses in conjugate vaccine development.

Beyond its use in conjugate vaccines, CRM197 has also been investigated for potential applications in targeted drug delivery and cancer research involving HB-EGF (heparin-binding epidermal growth factor-like growth factor).